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How It Works
BIXEPS UNDERLYING TECHNOLOGY

3 Main Mechanisms

MAGNETIC MITOHORMESIS
Magnetic mitohormesis

BIXEPS is tuned and optimised to activate the Mitochondria, the "powerhouse" in every cell.

EMPOWERING MUSCLE
Empowering muscle

Activated muscles adapt by producing more energy to perform longer and recover stronger.

UPREGULATING MYOKINES
upregulate myokines

Activated muscle release Myokines into our blood that regulate other bodily functions like our metabolism, regeneration, and immunity.

Muscle Myokine Medicine

Exercise is the best Medicine. But can be challenging.

Magnetic Mitohormesis facilitates Exercise as Medicine
Encouraging Myokine release to improve Regeneration, Inflammation & Metabolism.

  • Is BIXEPS safe?
    BIXEPS is safe and reliable. It uses low frequency and low energy electromagnetic fields that are safe and non-ionising (100Hz-10kHz range). These signals have magnetic field strengths that are a thousand times less than conventional MRI equipment, and are at levels similar to those of household appliances like hairdryers or shavers (World Health Organization). BIXEPS devices meet international electrical safety standards (IEC 60601) and have been certified safe for use by partner hospitals.
  • Will I feel anything when I use BIXEPS?
    The magnetic fields produced by BIXEPS are deceptively mild, but effective. They are within the realm of the natural magnetic fields produced by the Earth, only about 10-20 times larger. Therefore, our fields modulate the same biochemical processes that are governed by the Earth’s magnetic fields. Our proprietary technology lies in our ability to finely tune and deliver safe and uniform BIXEPS fields to the desired volumes of muscle. Different users report having different sensations while using BIXEPS, namely: slight warmth in their muscles, a tingling sensation, slight cooling or numbness in their legs or other parts of the body. A large number of users also report having no perceivable sensation. BIXEPS is safe and reliable, but should you experience pain or discomfort while using BIXEPS or at any time after, do stop and let your trainer, caregiver or doctor know.
  • Can I use BIXEPS if I have implants?
    Users with Active Electronic Implants like Pacemakers and Defribrillators should NOT use the BIXEPS device. Persons with passive implants who are able to go for MRI, can safely use BIXEPS. Dental implants and modern passive implants that are non-ferromagnetic are allowably used with much more powerful magnetic medical equipment like the MRI (that operates at field strengths a 1000x stronger than BIXEPS). Some older implants are “weakly magnetic” and are safe for MRI 6 weeks after surgery, these implants are safe to use with BIXEPS too (Institute for Magnetic Resonance Safety, Education and Research). Users who are unsure about the type of implants they have, and are unsure about using BIXEPS should consult with their doctors too.
  • Does clothing interfere with BIXEPS fields?
    No. The fields are designed to safely and gently reach deep into your muscles to activate the mitochondria within cells. These fields are not affected by clothing and shoes.
  • Why is each BIXEPS session only 10 minutes?
    Based on our scientific research, 10 minutes of exposure to BIXEPS fields yields optimal benefits. Shorter or longer exposures to the fields have been shown to render less mitochondria activity and therefore have less of an effect.
  • Will I get better results if I use BIXEPS more frequently?
    More frequent use of BIXEPS does not necessarily lead to better results. Similar to physical exercise, your body and muscles require a few days to respond and adapt to the physical challenges, but ultimately recover fitter / stronger / better able to deal with these challenges. The body adapts to BIXEPS in the same way. Our research has shown that muscles adapt to BIXEPS stimulation by recruiting more mitochondria to create more energy which over time leads to higher levels of energy in the muscles, but the process needs to be undertaken incrementally; we need to be patient and steadfast as good things come in small quantities. Weekly sessions are suitable for users with an average level of activity, who want to improve and/or maintain their fitness and health. Bi-weekly sessions are suitable for more active users who want a bigger challenge to train their bodies to create even more energetics or supportive myokine effects.
  • Can I use BIXEPS on both legs in a single session?
    Certainly! But more is not always better. We know from our users that using our devices on one leg each week is sufficient to create sufficient myokines that create systemic health benefits and enable users to have better function. In addition to enabling physical activity, our Muscle also play the role as a signaling organ that tells the rest of the body that it is being exercised and to adapt. In response to its activation, either through exercise or our magnetic field stimulation, muscle releases a variety of growth and metabolic factors collectively known as myokines. These signals trigger the rest of the body, including the non-treated leg, to adapt, getting fitter and healthier and ready for more physical activity. These adaptations take time and are also dependent on an individual’s existing health and lifestyle factors (e.g., diet and exercise). While activating both legs would result in more myokine signals, our results show that additional activation is not required for, or will necessarily result in additional gains. Hence single-leg use of BIXEPS is our recommendation as it is more efficient. This same phenomenon is well-known in the field of exercise science and sports, where training more than one muscle group in a single session is discouraged. While this leads to an increase in the adaptation of the muscles directly exposed, it may not necessarily result in faster systemic benefits. In cases where users start frail or with sedentary lifestyles, we recommend easing into things too.
  • Why must I use BIXEPS on my leg when it is not the site of my pain/injury?
    BIXEPS magnetic mitohormesis works by activating the mitochondria within muscle cells. This activation helps to increase energy production in muscles and promotes muscle repair and regeneration. Activated muscles then release signalling molecules, known as myokines, that circulate throughout the body to bring about systemic benefits such as enhanced metabolism and reduced inflammation. Any muscle group exposed to the fields will be activated and generate similar benefits. We therefore target the upper thighs, representing a large muscle mass, to provide the greatest delivery of myokines and provide the greatest benefits on our health and well-being.
  • Will BIXEPS help my muscles to become bulkier?
    No. BIXEPS magnetic mitohormesis encourages oxidative respiration in muscle. This encourages muscle endurance and its ability to withstand fatigue but does not necessarily correlate with an increase in muscle size. In fact, fatigue-resistant muscle is often leaner than other muscle types. Because BIXEPS provides muscles with more energy, you might find yourself having more energy to train harder and longer, and faster recovery post-exercise as well. Depending on the rest of your training programme, BIXEPS could enhance and amplify the outcomes of your various exercises, which could ultimately enhance muscle building as well.
  • Can I replace my regular exercise programme with BIXEPS?
    BIXEPS is NOT a replacement for physical exercise. Physical exercise gets our heart pumping and our blood flowing. Endorphins are released that elevate our mood. Physical activity also improves communication between our nerves and muscles. BIXEPS is designed to improve the efficiency of energy production in muscle that will in the long run facilitate and accelerate your journey towards a healthier and more active lifestyle.
  • How many weeks should I use BIXEPS for?
    We recommend a 12 week programme in most cases, as a minimum time period for our bodies to adjust and for the benefits of BIXEPS to build and become more obvious. (Note: Some users report improvements in fitness, endurance, pain and function much earlier but we recommend for them to complete the 12 weeks to enjoy the greater benefits that BIXEPS could bring.)
  • How long will I need to continue to use BIXEPS?
    While BIXEPS-related adaptations begin at the cellular level from the time each session commences, larger functional improvements may take time to build and consolidate, depending on individuals starting state and their other training or therapies at the time.
  • If I stop using BIXEPS, will my muscles weaken again?"
    Just like exercise, once you stop your BIXEPS sessions, your body will recalibrate and adapt to your new lifestyle. Continued physical exercises are recommended as an active lifestyle and physical exercise will help to maintain users' gains in muscle tone, fitness, and function.
Myokine Medicine

References: 1. Nieman, D. C., & Wentz, L. M. (2019). The compelling link between physical activity and the body's defense system. Journal of sport and health science, 8(3), 201-217. 2. Gomarasca, M., Banfi, G., & Lombardi, G. (2020). Myokines: The endocrine coupling of skeletal muscle and bone. In Advances in Clinical Chemistry (Vol. 94, pp. 155-218). Elsevier. 3. Hoffmann, C., & Weigert, C. (2017). Skeletal muscle as an endocrine organ: the role of myokines in exercise adaptations. Cold Spring Harbor perspectives in medicine, 7(11), a029793. 4. Jones, A. W., & Davison, G. (2019). Exercise, Immunity, and Illness. In Muscle and Exercise Physiology (pp. 317-344). Academic Press. 5. Lee, J. H., & Jun, H. S. (2019). Role of myokines in regulating skeletal muscle mass and function. Frontiers in physiology, 10. 6. Martinez-Huenchullan, S. F., Tam, C. S., Ban, L. A., Ehrenfeld-Slater, P., Mclennan, S. V., & Twigg, S. M. (2020). Skeletal muscle adiponectin induction in obesity and exercise. Metabolism, 102, 154008. 7. Campbell, K. L., Winters-Stone, K. M., Wiskemann, J., May, A. M., Schwartz, A. L., Courneya, K. S., ... & Morris, G. S. (2019). Exercise guidelines for cancer survivors: consensus statement from international multidisciplinary roundtable. Medicine & Science in Sports & Exercise, 51(11), 2375-2390. 8. Nieman, D. C., & Pence, B. D. (2019). Exercise immunology: Future directions. Journal of Sport and Health Science. 9. Patel, A. V., Friedenreich, C. M., Moore, S. C., Hayes, S. C., Silver, J. K., Campbell, K. L., ... & Denlinger, C. (2019). American College of Sports Medicine roundtable report on physical activity, sedentary behavior, and cancer prevention and control. Medicine & Science in Sports & Exercise, 51(11), 2391-2402. 10. Schmitz, K. H., Campbell, A. M., Stuiver, M. M., Pinto, B. M., Schwartz, A. L., Morris, G. S., ... & Patel, A. V. (2019). Exercise is medicine in oncology: engaging clinicians to help patients move through cancer. CA: a cancer journal for clinicians, 69(6), 468-484. 11. Louzada, R. A. N., Bouviere, J., Matta, L. P., Werneck de Castro, J. P. S., Dupuy, C., de Carvalho, D. P., & Fortunato, R. S. (2020). REDOX SIGNALING IN WIDESPREAD HEALTH BENEFITS OF EXERCISE. Antioxidants and Redox Signaling, (ja). 12. Van Wessel, T., De Haan, A., Van der Laarse, W. J., & Jaspers, R. T. (2010). The muscle fiber type–fiber size paradox: hypertrophy or oxidative metabolism?. European journal of applied physiology, 110(4), 665-694. 13. Wallings, R. L., Herrick, M. K., & Tansey, M. G. (2020). Linking mitochondria to the immune response. Elife, 9. 14. So, B., Kim, H. J., Kim, J., & Song, W. (2014). Exercise-induced myokines in health and metabolic diseases. Integrative medicine research, 3(4), 172-179. 15. Thyfault, J. P., & Bergouignan, A. (2020). Exercise and metabolic health: beyond skeletal muscle. Diabetologia, 1-11.

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