BIXEPS UNDERLYING TECHNOLOGY

3 Main Mechanisms

MAGNETIC MITOHORMESIS

BIXEPS is tuned and optimised to activate the Mitochondria, the "powerhouse" in every cell.

EMPOWERING MUSCLE

Activated muscles adapt by producing more energy to perform longer and recover stronger.

UPREGULATING MYOKINES

Activated muscle release Myokines into our blood that regulate other bodily functions like our metabolism, regeneration, and immunity.

Muscle Myokine Medicine

Exercise as Medicine.

Myokines are released during exercise and regulate multiple aspects of our health. Research into the effects of Myokines continues to build.

Learn more about the various effects of Myokines below and how BIXEPS could help.

Myokines regulate our Immunity and Inflammation


Exercise is known to affect our immune system. Many research scientists have studied the effects of exercise on immunity and our current understanding is that moderate levels of exercise can enhance our immunity, and reduce risk of upper respiratory-tract infections.

The recommended levels of exercise has been defined as between 30 to 60 minutes of moderate to vigorous-intensity exercise, five times a week. These moderate-intensity exercises include simple activities like running or brisk-walking.

Healthy moderate exercises increase the activity of our white blood cells that fight infections and diseases, while at the same time encouraging the muscular release of anti-inflammatory hormones like Interleukin-1 receptor antagonist and Interleukin-10. These myokines help to keep our inflammatory immune response from going overboard.

Scientific studies have shown that BIXEPS magnetic mitohormesis up-regulates these anti-inflammatory myokine levels and suggest the possibility for BIXEPS to be used to manage inflammation.




Myokines regulate Muscle Building and Muscle Energetics


Muscle loss happens naturally as we age and becomes a bigger problem with increasingly sedentary lifestyles. Maintaining muscle mass is key to preserve muscle strength, function and independence. Exercise remains the best intervenion to prevent such muscle loss.

When we exercise, our muscles contract and myokines are released to both encourage muscle regeneration and to prevent degeneration. Myokines associated with muscle mass regulation include Myostatin, Irisin, Interleukin-15 and Decorin, which have been observed to promote muscle growth and reduce muscle wastage. Other myokines like Myonectin and Fibroblast Growth Factor 21, do not only regulate muscle mass, but also influence mitochondrial health and the energy available for performance and regeneration.

BIXEPS magnetic mitohormesis was shown in pilot clinical studies to up-regulate Folistatin and Osteopontin levels. These myokines improve muscle and bone regneration respectively. After surgery, patients receiving BIXEPS were observed to have lower levels of blood biomarkers indicating muscle and bone breakdown as well. With several months of use, BIXEPS users also had improved muscle energetics which meant more energy in muscles to perform and recover.

Of note, studies have shown an inverse relationship between muscle size and its oxidative capacity, i.e. its ability to produce energy for sustained actions. BIXEPS has been shown to prefentially improve oxidative capacity within muscle. This suggests the possibility for BIXEPS to improve functional outcomes like balance and gait, without creating obvious gains in muscle mass.




Myokines regulate Metabolism


Regular exercise is a robust modulator of metabolism and a powerful protective agent against metabolic disease. Both acute events driven by each exercise bout and chronic adaptations from exercise help to regulate insulin sensitivity and reduce the risk of metabolic diseases, such as type 2 diabetes. While many of the metabolic health benefits of exercise depend on skeletal muscle adaptations, there are also exercised-induced adaptations in the liver, adipose tissue, vasculature and pancreas. Myokines and other signalling molecules are involved in inter-tissue communication to bring about these metabolic health benefits.

A major myokine involved in metabolism and obesity is Adiponectin, which functions to improve insulin-sensitivity and reduce inflammation. Studies have shown that muscle can be induced to release more Adiponectin in response to high-fat diets and inflammation, providing a "protective-mechanism" agains metabolic insults. Sustained high fat diets can cause this protective response to become dysregulated. But exercise can help prevent and even reverse this damage.

Another myokine involved in maintaining healthy brain metabolism and mitochondria health is Irisin. Exercise has been shown to increase levels of circulating Irisin and its pre-cursor Fibronectin type III domain-containing protein 5 (FNDC5). Exercise has also been shown to increase levels of PGC-1α, a co-factor, through which the effects of Irisin takes place.

BIXEPS has been shown in pre-clinical models to increase FNDC5 and PGC-1α levels in sedentary animals. This suggests the possibility for BIXEPS to enhance the benefits of Irisin in both brain and mitochondria health.




Myokines can aid with Cancer prevention and therapy


There is strong evidence showing that increased physical activity is beneficial for the prevention of at least 7 types of cancer (breast, colon, endometrial, kidney, bladder, esophageal and stomach), lowering the risks of these cancers anywhere from 10% to 24% (varied percentages for the different types of cancers).

Increasing evidence also shows that the prescription of exercise can improve cancer treatment, by acting synergistically with other interventions like surgery and chemotherapy. During recovery, exercise also improves long-term survival-related health outcomes such as anxiety, depression and fatigue and increases the quality of life of cancer survivors.

One mechanism by which exercise affects cancer outcomes would be through moderating the immune system in humans. Studies suggest that the contraction of skeletal muscle facilitate immune cell infiltration into tumours via the release of a myokine, Interleukin-6. Pre-clinical models show an upregulation of Interleukin-6 levels with BIXEPS use, which suggests that synergies with immunotherapy treatment strategies could exist.

Preliminary bench-top research has also shown that the myokine "soup" produced by muscle cells exposed to BIXEPS has a direct inhibitory effect on cancer cell growth, limiting the size and vascularisaion of breast-cancer tissue in pre-clinical models.





 

References:

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2. Gomarasca, M., Banfi, G., & Lombardi, G. (2020). Myokines: The endocrine coupling of skeletal muscle and bone. In Advances in Clinical Chemistry (Vol. 94, pp. 155-218). Elsevier.

3. Hoffmann, C., & Weigert, C. (2017). Skeletal muscle as an endocrine organ: the role of myokines in exercise adaptations. Cold Spring Harbor perspectives in medicine, 7(11), a029793.

4. Jones, A. W., & Davison, G. (2019). Exercise, Immunity, and Illness. In Muscle and Exercise Physiology (pp. 317-344). Academic Press.

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10. Schmitz, K. H., Campbell, A. M., Stuiver, M. M., Pinto, B. M., Schwartz, A. L., Morris, G. S., ... & Patel, A. V. (2019). Exercise is medicine in oncology: engaging clinicians to help patients move through cancer. CA: a cancer journal for clinicians, 69(6), 468-484.

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